Of course you can,

Using the example I give you, just take the Valid to is Less than the time the event is scheduled:

And instead of send a email in the In the for each records, you can use Update value: Active to "False". Or you can delete the record.

If you want to compare Dates yo can use Date Compare in the Flow and using a if condition:

Just need to use your triggers, when you want to trigger or schedule.

Hope that help you.